Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
206-374-1102
Fax:
206-577-4565
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene Name: NLR family, pyrin domain containing 3
Synonyms: NLRP3, AGTAVPRL, AII, C1orf7, Caterpiller protein 1.1, Cryopyrin, FCAS, FCU, PYPAF1, NALP3, CIAS1, CLR1.1, MWS
Target Sequences: NM_004895 NP_004886.3 Q96P20

Publications (17)

1
Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Walsh JG, Reinke SN, Mamik MK, McKenzie BA, Maingat F, Branton WG, Broadhurst DI, Power C. Retrovirology. 2014 11:35. (IHC; Human) [Full Text Article] [PubMed:24886384] [PMC:PMC4038111] Related Antibodies: LS-B4321.
2
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. Coucha M, Mohamed IN, Elshaer SL, Mbata O, Bartasis ML, El-Remessy AB. World journal of diabetes. 2017 8:56-65. (WB; Rat) [Full Text Article] [PubMed:28265343] [PMC:PMC5320749] Related Antibodies: LS-B4321.
3
LRRC8/VRAC anion channels enhance ß-cell glucose sensing and insulin secretion. Stuhlmann T, Planells-Cases R, Jentsch TJ. Nature communications. 2018 May;9:1974. (Human) [Full Text Article] [PubMed:29773801] [PMC:PMC5958052]
4
Deletion of Thioredoxin-Interacting Protein (TXNIP) Abrogates High Fat Diet-induced Retinal Leukostasis, Barrier Dysfunction and Microvascular Degeneration in a Mouse Obesity Model. Islam N Mohamed, Nader Sheibani, Azza B El-Remessy. International journal of molecular sciences. 2020 June;21: [Full Text Article] [PubMed:32492941] [PMC:PMC7312035] Related Antibodies: LS-B4321.
5
Fructose stimulated de novo lipogenesis is promoted by inflammation. Jelena Todoric, Giuseppe Di Caro, Saskia Reibe, Darren C Henstridge, Courtney R Green, Alison Vrbanac, Fatih Ceteci, Claire Conche, Reginald McNulty, Shabnam Shalapour, Koji Taniguchi, Peter J Meikle, Jeramie D Watrous, Rafael Moranchel, Mahan Najhawan, Mohit Jain, Xiao Liu, Tatiana Kisseleva, Maria T Diaz-Meco, Jorge Moscat, Rob Knight, Florian R Greten, Lester F Lau, Christian M Metallo, Mark A Febbraio, Michael Karin. Nature metabolism. 2020 October;2:1034-1045. [Full Text Article] [PubMed:32839596] [PMC:PMC8018782] Related Antibodies: LS-C334192.
6
Embryonic stem cell-derived exosomes inhibit doxorubicin-induced TLR4-NLRP3-mediated cell death-pyroptosis. Zahra Tavakoli Dargani, Dinender K Singla. American journal of physiology. Endocrinology and metabolism. 2019 August;317:H460-H471. [Full Text Article] [PubMed:31172809] [PMC:PMC6732475] Related Antibodies: LS-B4321.
7
Blockade of ß-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis. Shipeng Dang, Zhen-Ye Zhang, Ku-Lin Li, Jie Zheng, Ling-Ling Qian, Xiao-Yu Liu, Ying Wu, Chang-Ying Zhang, Xiao-Xi Zhao, Zhi-Ming Yu, Ru-Xing Wang, Tingbo Jiang. Annals of translational medicine. 2020 February;8:127. [Full Text Article] [PubMed:32175420] [PMC:PMC7048978] Related Antibodies: LS-C334192.
8
Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Sally L Elshaer, Islam N Mohamed, Maha Coucha, Sara Altantawi, Wael Eldahshan, Megan L Bartasi, Ahmed Y Shanab, Renee Lorys, Azza B El-Remessy. Antioxidants (Basel, Switzerland). 2017 Jun;6:47. [Full Text Article] [PubMed:28661427] [PMC:PMC5618075] Related Antibodies: LS-B4321.
9
Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. P M Abdul-Muneer, Saleena Alikunju, Vikas Mishra, Heather Schuetz, Adam M Szlachetka, Ellen L Burnham, James Haorah. Brain, behavior, and immunity. 2017 May;62:291-305. [Full Text Article] [PubMed:28232172] [PMC:PMC6378699] Related Antibodies: LS-C148764.
10
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Maha Coucha, Ahmed Y Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B El-Remessy. International journal of molecular sciences. 2019 Aug;20:3969. [Full Text Article] [PubMed:31443163] [PMC:PMC6721134] Related Antibodies: LS-B4321.
11
Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion. Ibolya E András, Marta Garcia-Contreras, Christopher Yanick, Paola Perez, Brice Sewell, Leonardo Durand, Michal Toborek. Molecular brain. 2019 Feb;13:21. [Full Text Article] [PubMed:32066471] [PMC:PMC7027073] Related Antibodies: LS-B4321.
12
Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Ran Cheng , Sandrine Billet , Chuanxia Liu, Subhash Haldar, Diptiman Choudhury, Manisha Tripathi, Monirath Hav, Akil Merchant, Tao Hu, Haiyun Huang, Hongmei Zhou, Neil A Bhowmick. Oncogene. 2020 Feb;39:1543-1556. [Full Text Article] [PubMed:31685946] [PMC:PMC7018659] Related Antibodies: LS-C162911.
13
NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation. Francis M Hughes Jr, Nathan A Hirshman, Brian M Inouye, Huixia Jin, Eloise W Stanton, Chloe E Yun, Leah G Davis, Jonathan C Routh, J Todd Purves. Diabetes. 2019 Feb;68:430-440. [Full Text Article] [PubMed:30425063] [PMC:PMC6341307] Related Antibodies: LS-C334192.
14
Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]
15
Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. Faith L Anderson, Katharine M von Herrmann, Angeline S Andrew, Yuliya I Kuras, Alison L Young, Clemens R Scherzer, William F Hickey, Stephen L Lee, Matthew C Havrda. NPJ Parkinson's disease. 2021 Jan;7:2. [Full Text Article] [PubMed:33398042] [PMC:PMC7782812]
16
Implication of the NLRP3 Inflammasome in Bovine Age-Related Sarcopenia. Davide De Biase, Giuseppe Piegari, Francesco Prisco, Ilaria Cimmino, Ilaria d'Aquino, Valeria Baldassarre, Francesco Oriente, Serenella Papparella, Orlando Paciello. International journal of molecular sciences. 2021 Mar;22:3609. [Full Text Article] [PubMed:33808510] [PMC:PMC8036417] Related Antibodies: LS-B8262.
17
Inflammasome-mediated neurodegeneration following heart disease. Kuan Cheng #, Jingjing Wang #, Qingxing Chen, Gang Zhao, Yang Pang, Ye Xu, Junbo Ge, Wenqing Zhu. Annals of Translational Medicine. 2021 Oct;;9:1560. [Full Text Article] [PubMed:34790766] [PMC:PMC8576725]
more

☰ Filters
Antibodies (58)
Proteins (11)
ELISA Kits (8)
Over-Expression Lysate (6)
Primary (58)
Recombinant (5)
Sandwich (7)
Sandwich CLIA (1)
NALP3 / NLRP3 (77)
Human (55)
Mouse (26)
Rat (7)
Bovine (1)
Dog (4)
Gibbon (3)
Monkey (8)
IHC (17)
IHC-Fr (1)
IHC-P (13)
WB (41)
Flo (1)
ELISA (19)
ICC (4)
IF (8)
IP (2)
Peptide-ELISA (5)
rabbit (51)
mouse (4)
goat (3)
Product Group
Coronavirus Antibodies Proteins cDNAs (66)
Coronavirus Detection (8)
Cytokine Release Syndrome (74)
Cytokine Release Syndrome Antibodies (55)
Cytokine Release Syndrome Proteins (11)
ELISA Kits for Cytokine Release Syndrome Targets (8)
IHCPlus (4)
PathPlus Cancer (2)
IgG (32)
IgG1 (2)
IgG2b (1)
IgG2b,k (1)
monoclonal mc (4)
polyclonal pc (54)
1D4B (1)
25N10E9 (1)
Cryo-1 (1)
Nalpy3-b (1)
96-Well Strip Plate (8)
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (36)
aa65-91 (8)
aa671-1033 (8)
aa158-207 (4)
501-550 aa, Internal (1)
C-Terminus (1)
Internal (1)
Internal Region (1)
N-Terminal (1)
Ser295 (1)
aa1-50 (1)
aa1-93 (1)
aa12-31 (1)
aa21-194 (1)
aa216-385 (1)
aa4-223 (1)
aa81-93 (1)
aa82-93 (1)
aa974-1036 (1)
No (69)
Yes (8)
Cell Lysates (3)
Plasma (5)
Serum (5)
Tissue Homogenates (5)
6His, N-terminus + 6His, C-terminus (1)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (6)
Human (6)
Mouse (2)
293T Cells (3)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
NALP3 / NLRP3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) Antibody
Dog, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NALP3 / NLRP3 Antibody - Anti-NALP3 / NLRP3 antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) (Biotin) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
NALP3 / NLRP3 Antibody - Anti-NLRP3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
NALP3 / NLRP3 Mouse anti-Human Monoclonal (Nalpy3-b ) Antibody
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$485
NALP3 / NLRP3 Antibody - NLRP3 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lymph tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$381
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µl/$376
NALP3 / NLRP3 Antibody - Anti-NLRP3 antibody IHC of human peripheral blood leukocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
NALP3 / NLRP3 Goat anti-Human Polyclonal (aa82-93) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$440
NALP3 / NLRP3 Antibody - Western blot analysis of extracts of K-562 cell line, using NLRP3 antibody.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
NALP3 / NLRP3 Antibody - Western blot of NALP3 / NLRP3 antibody.
Select
NALP3 / NLRP3 Rabbit anti-Mouse Polyclonal (aa671-1033) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
100 µl/$302; 200 µl/$345; 500 µl/$489; 1 ml/$561
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
NALP3 / NLRP3 Protein - Recombinant NLR Family, Pyrin Domain Containing Protein 3 By SDS-PAGE
Select
E. coli
His, N-Terminal
43.9 kDa
10 µg/$271; 50 µg/$422; 100 µg/$672; 200 µg/$841; 1 mg/$1,880; 500 µg/$1,394; 5 mg/$4,068
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$744
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
NALP3 / NLRP3 Protein - 12.5% SDS-PAGE of human NLRP3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
144.6 kDa
2 µg/$429
NALP3 / NLRP3 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$821
Select
E. coli
316 AA
6His, N-terminus + 6His, C-terminus
Less than 0.1 EU/µg protein (determined by LAL method).
34.87 kDa
10 mg/$4,268; 5 mg/$3,202; 1 mg/$1,868; 0.5 mg/$1,362; 200 µg/$1,023; 100 µg/$710; 50 µg/$521
NALP3 / NLRP3 Antibody - NALP3 / NLRP3 antibody. IHC(P): Human Tonsil Tissue.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa12-31) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$421
Select
NALP3 / NLRP3 Mouse anti-Human Monoclonal (aa4-223) (1D4B) Antibody
Human
ICC
Unconjugated
100 µg/$787
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$828
NALP3 / NLRP3 Antibody - Western blot analysis of NLRP3 expression in SHSY5Y (A); THP1 (B) whole cell lysates.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
30 µl/$245; 100 µl/$289; 200 µl/$341
NALP3 / NLRP3 Antibody - NALP3 / NLRP3 antibody (5µg/ml) staining of paraffin embedded Human Peripheral Blood Leukocytes. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Select
NALP3 / NLRP3 Goat anti-Human Polyclonal (C-Terminus) Antibody
Human
Flo, IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µg/$455
NALP3 / NLRP3 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
NALP3 / NLRP3 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
68.6 - 50000 pg/ml
Chemiluminescent
Cell Lysates, Tissue Homogenates
1 Plate/$917
Viewing 1-25 of 77 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).