NALP3 / NLRP3

NLR family, pyrin domain containing 3

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

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Antibodies (53)

Proteins (11)

ELISA Kits (8)

Type

Over-Expression Lysate (6)

Primary (53)

Recombinant (5)

Sandwich (7)

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Target

NALP3 / NLRP3 (72)

Reactivity

Human (50)

Mouse (24)

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Application

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monoclonal mc (4)

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Yes (8)

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E. coli (3)

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Low endotoxin level (1)

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PathPlus™ NALP3 / NLRP3 Antibody LS-B4321

Cancer

(5.0) Rating

(7) Publication(s)

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$545

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PathPlus™ NALP3 / NLRP3 Antibody (aa158-207) LS-B8262

Cancer

(5.0) Rating

(2) Publication(s)

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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NALP3 / NLRP3 Antibody (aa158-207, Biotin) LS-C470765

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa158-207) (Biotin) Antibody

Reactivity:

Dog, Human, Monkey, Gibbon

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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IHC-plus™ NALP3 / NLRP3 Antibody (clone Nalpy3-b) LS-B5028

(4.0) Rating

Antibody:

NALP3 / NLRP3 Mouse anti-Human Monoclonal (Nalpy3-b ) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$495

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NALP3 / NLRP3 Antibody (aa65-91) LS-C162911

(4.0) Rating

(1) Publication(s)

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ NALP3 / NLRP3 Antibody (aa82-93) LS-B1767

(4.0) Rating

Antibody:

NALP3 / NLRP3 Goat anti-Human Polyclonal (aa82-93) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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NALP3 / NLRP3 Antibody (aa1-50) LS-C148764

(4.0) Rating

(1) Publication(s)

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

0.2 ml/$386

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NALP3 / NLRP3 Antibody LS-C334192

(4.2) Rating

(3) Publication(s)

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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NALP3 / NLRP3 Antibody (aa671-1033) LS-C374964

Antibody:

NALP3 / NLRP3 Rabbit anti-Mouse Polyclonal (aa671-1033) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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Mouse NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17336

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17337

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Bovine NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F17338

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Bovine

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse NALP3 / NLRP3 Protein (Recombinant His, N-Terminal) (aa671-1033) - LS-G26053

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

43.9 kDa

Price:

10 µg/$281; 50 µg/$442; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176

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Human NALP3 / NLRP3 Protein (Recombinant GST) (Full Length) - LS-G36168

(4.0) Rating

(1) Publication(s)

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

144.6 kDa

Price:

2 µg/$439

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Human NALP3 / NLRP3 (CLIA) ELISA Kit - LS-F38859

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

68.6 - 50000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$851

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F31954

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F32087

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Human NALP3 / NLRP3 (Sandwich ELISA) ELISA Kit - LS-F39626

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Human NALP3 / NLRP3 Protein (Recombinant 6His, N-terminus + 6His, C-terminus) (aa220-536) - LS-G140977

Source:

E. coli

Sequence Length:

316 AA

Tag:

6His, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

34.87 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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NALP3 / NLRP3 Antibody (aa4-223, clone 1D4B) LS-C189819

Antibody:

NALP3 / NLRP3 Mouse anti-Human Monoclonal (aa4-223) (1D4B) Antibody

Reactivity:

Human

Applications:

ICC

Format:

Unconjugated

Price:

100 µg/$896

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NALP3 / NLRP3 Antibody (aa12-31) LS-C312821

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa12-31) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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NALP3 / NLRP3 Antibody (501-550 aa, Internal) LS-C387147

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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NALP3 / NLRP3 Antibody (aa65-91, Biotin) LS-C279939

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (aa65-91) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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NALP3 / NLRP3 Antibody (Internal) LS-C368954

Antibody:

NALP3 / NLRP3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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NALP3 / NLRP3 Antibody (C-Terminus) LS-C47546

Antibody:

NALP3 / NLRP3 Goat anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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