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PathPlusTM IDH1 / IDH Antibodies
IDH1 is a nuclear enzyme found in cells throughout the body with highest expression in male reproductive tissues, the adrenal gland, liver, breast, the gastrointestinal tract, endometrium and adipose tissue. It is functionally involved in DNA repair, metabolism and epigenetic regulation. IDH1 is frequently mutated in specific types of cancer; for example, the IDH1 mutation R132H is common in secondary glioblastomas, and antibodies specific to this mutation are used in the diagnosis of astrocytomas and oligodendroglial tumors where the mutation has a 70% rate of occurrence. R132H mutation IDH1 antibodies distinguish astrocytoma from primary glioblastomas, and differentiate diffuse astrocytoma grade II from ependymoma or pilocytic astrocytoma. They also stain positively in around 12% of acute myeloid leukemia. In addition, antibodies that recognize wild-type IDH1 may be used as a control alongside mutation-specific antibodies in the differential diagnosis of secondary glioblastomas (mutation positive) from primary glioblastomas (majority are mutation negative). References: Oncogene. 2018. 37, 1949–1960, DOI: 10.1038/s41388-017-0077-z; Curr Neurol Neurosci Rep. 2013 May;13(5):345, PMID: 23532369; PLoS One. 2017 Jan 4;12(1):e0169038, PMID: 28052098; Cell Rep. 2018 Oct 23;25(4):1018-1026.e4, PMID: 30355481; Am J Clin Pathol. 2011 Jan;135(1):35-45, PMID: 21173122;

6 PathPlusTM Antibodies
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Antibodies (6)
Primary (6)
IDH1 / IDH (6)
Human (6)
Mouse (3)
Rat (2)
Pig (2)
IHC (3)
IHC-P (6)
WB (6)
Flo (1)
ELISA (1)
ICC (3)
IF (2)
rabbit (3)
mouse (3)
Product Group
PathPlus Cancer (6)
PathPlus Cancer Pathology (6)
IgG (1)
IgG2a,k (3)
monoclonal mc (3)
polyclonal pc (3)
AT25H10 (1)
C12 (1)
C13 (1)
Unconjugated (6)
aa116-143 (1)
aa290-339 (1)
No (6)
IDH1 / IDH Antibody - Anti-IDH1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Cancer Pathology
Cancer
IDH1 / IDH Rabbit anti-Human Polyclonal (aa290-339) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
IDH1 / IDH Antibody - Anti-IDH1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer Pathology
Cancer
IDH1 / IDH Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IDH1 / IDH Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
IDH1 / IDH Mouse anti-Human Monoclonal (AT25H10) Antibody
Human
ELISA, ICC, IF, IHC-P, WB
Unconjugated
100 µl/$460
IDH1 / IDH Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
IDH1 / IDH Mouse anti-Human Monoclonal (C13) Antibody
Mouse, Pig, Human
ICC, IHC-P, WB
Unconjugated
50 µl/$460
IDH1 / IDH Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
IDH1 / IDH Rabbit anti-Human Polyclonal (aa116-143) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
IDH1 / IDH Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
IDH1 / IDH Mouse anti-Human Monoclonal (C12) Antibody
Mouse, Rat, Pig, Human
ICC, IHC-P, WB
Unconjugated
50 µl/$460
Viewing 1-6 of 6 product results