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ADAM17 / TACE
ADAM metallopeptidase domain 17
Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease.
| Gene Name: | ADAM metallopeptidase domain 17 |
| Family/Subfamily: | Protease , Metallopeptidase M12B |
| Synonyms: | ADAM17, CD156B, CD156b antigen, CSVP, ADAM 17, NISBD, TNF-alpha converting enzyme, TNF-alpha convertase, TNF-alpha-converting enzyme, Snake venom-like protease, TACE |
| Target Sequences: | NM_003183 NP_003174.3 P78536 |
Publications (4)
1
CD44 Interacts with HIF-2a to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells. Johansson E, Grassi ES, Pantazopoulou V, Tong B, Lindgren D, Berg TJ, Pietras EJ, Axelson H, Pietras A. Cell reports. 2017 20:1641-1653. (IF; Mouse)
[Full Text Article]
[PubMed:28813675]
2
Renal endothelial protein C receptor expression and shedding during diabetic nephropathy. Lattenist L, Ochodnický P, Ahdi M, Claessen N, Leemans JC, Satchell SC, Florquin S, Gerdes VE, Roelofs JJ. Journal of thrombosis and haemostasis : JTH. 2016 June;14:1171-82. (Human)
[Full Text Article]
[PubMed:26990852]
3
ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance. Jacob J Orme, Khalid A Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M Cristine Charlesworth, Tariq U Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S Mansfield, Roxana S Dronca, Haidong Dong. Oncoimmunology. 2020 May;9:1744980. [Full Text Article]
[PubMed:32363112]
[PMC:PMC7185206]
Related Antibodies: LS-B4426.
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(2)
ADAM17 / TACE Mouse anti-Human Monoclonal (1F6) Antibody
Human
ELISA, IHC, IHC-P, PLA, WB
Unconjugated
50 µg/$440
ADAM17 / TACE Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, ICC, IF, WB
Unconjugated
0.1 mg/$460
ADAM17 / TACE Rabbit anti-Human Polyclonal (pThr735) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADAM17 / TACE Goat anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa195-224) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
ADAM17 / TACE Mouse anti-Human Monoclonal (aa1-671) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$860
ADAM17 / TACE Rabbit anti-Human Polyclonal (670-750 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa196-245) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
ADAM17 / TACE Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
ADAM17 / TACE Rabbit anti-Human Polyclonal (670-750 aa) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ADAM17 / TACE Mouse anti-Human Monoclonal (Preservative Free) (5H4-F10-E11) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
ADAM17 / TACE Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$832
ADAM17 / TACE Rabbit anti-Human Polyclonal (aa806-824) Antibody
Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
100 µl/$412
ADAM17 / TACE Rabbit anti-Human Polyclonal (pThr735) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ADAM17 / TACE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
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