BRCA1

breast cancer 1, early onset

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.

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Products

Antibodies (151)

ELISA Kits (10)

Proteins (7)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (3)

Primary (151)

Recombinant (7)

Sandwich (5)

Target

BRCA1 (168)

Reactivity

Human (139)

Mouse (32)

Rat (29)

Chimpanzee (6)

Dog (1)

Gibbon (3)

Monkey (5)

Orangutan (3)

Application

IHC (47)

IHC-Fr (1)

IHC-P (18)

WB (132)

Flo (1)

ELISA (27)

ICC (13)

IF (34)

IP (36)

Peptide-ELISA (9)

Host

rabbit (110)

mouse (40)

sheep (1)

Product Group

IHCPlus (2)

PathPlus Cancer (1)

Isotype

IgG (64)

IgG1 (21)

IgG2a (2)

IgG3,k (1)

Clonality

monoclonal mc (39)

polyclonal pc (112)

Clone

17F8 (2)

6B4 (2)

6C6D2 (1)

8F7 (1)

BR64 (1)

KEN (5)

MS110 (1)

MS13 (1)

MU (5)

OTI1C4 (2)

OTI2A5 (2)

OTI5D10 (2)

OTI6H10 (2)

OTI7B12 (2)

RAY (5)

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Format

96-Well Microplate (2)

96-Well Strip Plate (8)

APC (3)

APC Conjugated (4)

Azide-free (1)

Biotin Conjugated (10)

Carrier-free (5)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

DY488 Conjugated (3)

DY550 Conjugated (3)

DY650 Conjugated (3)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (4)

Unconjugated (104)

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Epitope

aa1314-1864 (18)

aa1151-1473 (10)

aa1524-1781 (8)

aa1579-1811 (8)

aa19-83 (8)

pSer1423 (8)

pSer1524 (8)

aa443-472 (7)

N-Terminus (4)

aa1151-1200 (4)

pSer1457 (4)

C-Terminus (3)

N-Terminal (3)

aa341-748 (3)

1360-1440 aa (2)

aa700-750 (2)

aa762-1315 (2)

pSer988 (2)

1400-1480 aa (1)

1460-1540 aa (1)

930-1010 aa (1)

Internal (1)

Ser1423 (1)

aa1301-1863 (1)

aa1423-1472 (1)

aa1491-1540 (1)

aa1634-1863 (1)

aa1661-1863 (1)

aa1800-C-term (1)

aa1848-1863 (1)

aa229-335 (1)

aa250-300 (1)

aa955-1004 (1)

p1423 (1)

p1457 (1)

p1524 (1)

pSer1189 (1)

pSer1280 (1)

pSer1387 (1)

pSer1466 (1)

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Publications

No (168)

Sample Type

Adherent Cell Cultures (2)

Cell Lysates (1)

Plasma (4)

Serum (4)

Tissue Homogenates (2)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-terminus (1)

His-GST (1)

His-T7 (1)

Species

Human (5)

Mouse (1)

Rat (1)

Source

E. coli (5)

Wheat Germ Extract (2)

Purification

Purified (2)

Select

BRCA1 Antibody LS-C330840

Antibody:

BRCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

BRCA1 Antibody (aa1661-1863) LS-C313408

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (aa1661-1863) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

PathPlus™ BRCA1 Antibody (aa341-748, clone 8F7) LS-B4783

Cancer

(5.0) Rating

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa341-748) (8F7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$440

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BRCA1 Antibody (aa1524-1781) LS-C314778

Antibody:

BRCA1 Rabbit anti-Mouse Polyclonal (aa1524-1781) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

Select

BRCA1 Antibody (aa762-1315, clone 17F8) LS-C19931

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa762-1315) (17F8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

BRCA1 Antibody (aa1314-1864, clone RAY) LS-C2620

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa1314-1864) (RAY) Antibody

Reactivity:

Human

Applications:

ICC, IF, IP, WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

Human BRCA1 (Sandwich ELISA) ELISA Kit - LS-F4584

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Mouse BRCA1 (Sandwich ELISA) ELISA Kit - LS-F15446

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

BRCA1 Antibody (aa1314-1864) LS-C77221

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa1314-1864) Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

100 µl/$634

Select

BRCA1 Antibody (aa762-1315) LS-C83427

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa762-1315) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$563

Select

BRCA1 Antibody (HRP) LS-C210784

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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BRCA1 Antibody (C-Terminus) LS-C413059

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$341

Select

BRCA1 Antibody (C-Terminus) LS-C413127

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$321

Select

BRCA1 Antibody (phospho-Ser1524) LS-C286949

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (pSer1524) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$533

Select

BRCA1 Antibody (aa443-472) LS-C156856

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (aa443-472) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

IHC-plus™ BRCA1 Antibody (aa1848-1863) LS-B16393

(4.0) Rating

Antibody:

BRCA1 Mouse anti-Human Polyclonal (aa1848-1863) Antibody

Reactivity:

Human, Monkey

Applications:

IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$485

Select

BRCA1 Antibody LS-C659510

Antibody:

BRCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

BRCA1 Antibody (1360-1440 aa) LS-C382347

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (1360-1440 aa) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

IHC-plus™ BRCA1 Antibody (Ser1423) LS-B1176

(4.0) Rating

Antibody:

BRCA1 Rabbit anti-Human Polyclonal (Ser1423) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

BRCA1 Antibody (N-Terminal, clone MS110) LS-C745675

Antibody:

BRCA1 Mouse anti-Human Monoclonal (N-Terminal) (MS110) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$487

Select

BRCA1 Antibody LS-C747003

Antibody:

BRCA1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

BRCA1 Antibody (aa229-335, clone 6C6D2) LS-C191861

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa229-335) (6C6D2) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

BRCA1 Antibody (aa1314-1864, clone KEN) LS-C2619

Antibody:

BRCA1 Mouse anti-Human Monoclonal (aa1314-1864) (KEN) Antibody

Reactivity:

Human

Applications:

ICC, IF, IP, WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

BRCA1 Antibody (clone 17F8) LS-C745834

Antibody:

BRCA1 Mouse anti-Human Monoclonal (17F8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$556

Select

BRCA1 Antibody (clone 6B4) LS-C746151

Antibody:

BRCA1 Mouse anti-Human Monoclonal (6B4) Antibody

Reactivity:

Human

Applications:

IF, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$556

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