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CASP6 / Caspase 6
caspase 6, apoptosis-related cysteine peptidase
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.
| Gene Name: | caspase 6, apoptosis-related cysteine peptidase |
| Family/Subfamily: | Protease , Cysteine C14 |
| Synonyms: | CASP6, Apoptotic protease Mch-2, Caspase 6, CASP-6, Caspase-6, Mch-2, MCH2 |
| Target Sequences: | NM_001226 NP_001217.2 P55212 |
Publications (4)
1
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Cell death and differentiation. 2014 21:696-706. (ICC; Human)
[Full Text Article]
[PubMed:24413155]
[PMC:PMC3978300]
Related Antibodies: LS-B477.
2
Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. Li W, Tan C, Liu Y, Liu X, Wang X, Gui Y, Qin L, Deng F, Yu Z, Hu C, Chen L. Molecular medicine reports. 2015 November;12:7756-62. (Human)
[Full Text Article]
[PubMed:26458999]
3
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P Jesper Sjöström, Andrea C LeBlanc. Acta neuropathologica communications. 2019 Dec;7:210. [Full Text Article]
[PubMed:31843022]
[PMC:PMC6915996]
Related Antibodies: LS-B477.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (Cleavage Site) Antibody
Rabbit, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$565
CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (120-200 aa, Internal) Antibody
Mouse, Rat
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Goat anti-Human Polyclonal (aa253-267) Antibody
Rabbit, Mouse, Rat, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (90-170 aa, Internal) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa130-179) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (p257) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa223-272) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (Cleaved Asp179) Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (200-280 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (200-280 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa24-293) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa24-293) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CASP6 / Caspase 6 Rabbit anti-Rat Polyclonal (aa7-27) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (aa144-193) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$546
CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (Cleaved-Asp162) Antibody
Mouse, Rat
ELISA, IHC, WB
Unconjugated
100 µg/$357
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