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CASP6 / Caspase 6

caspase 6, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.

Gene Name: caspase 6, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP6, Apoptotic protease Mch-2, Caspase 6, CASP-6, Caspase-6, Mch-2, MCH2
Target Sequences: NM_001226 NP_001217.2 P55212

Publications (4)

1
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Cell death and differentiation. 2014 21:696-706. (ICC; Human) [Full Text Article] [PubMed:24413155] [PMC:PMC3978300] Related Antibodies: LS-B477.
2
Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. Li W, Tan C, Liu Y, Liu X, Wang X, Gui Y, Qin L, Deng F, Yu Z, Hu C, Chen L. Molecular medicine reports. 2015 November;12:7756-62. (Human) [Full Text Article] [PubMed:26458999]
3
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P Jesper Sjöström, Andrea C LeBlanc. Acta neuropathologica communications. 2019 Dec;7:210. [Full Text Article] [PubMed:31843022] [PMC:PMC6915996] Related Antibodies: LS-B477.
4
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Anastasia Noël , Bénédicte Foveau , Andréa C LeBlanc. Cell death & disease. 2021 Mar;12:227. [Full Text Article] [PubMed:33649324] [PMC:PMC7921451] Related Antibodies: LS-B477.
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CASP6 / Caspase 6 Antibody - Anti-Caspase 6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP6 / Caspase 6 Antibody - Anti-Caspase 6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (Cleavage Site) Antibody
Rabbit, Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$565
CASP6 / Caspase 6 Antibody - Western blot of Cleaved-Caspase-6 p18 (D162) antibody
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CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (120-200 aa, Internal) Antibody
Mouse, Rat
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Antibody - CASP6 antibody (0.5 ug/ml) staining of Human Colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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CASP6 / Caspase 6 Goat anti-Human Polyclonal (aa253-267) Antibody
Rabbit, Mouse, Rat, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
CASP6 / Caspase 6 Antibody - Immunohistochemical analysis of Caspase 6 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP-conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP6 / Caspase 6 Antibody - Anti-Caspase 6 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP6 / Caspase 6 Antibody - Western blot of Cleaved-Caspase-6 p18 (D179) antibody
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (90-170 aa, Internal) Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CASP6 / Caspase 6 Antibody - Immunohistochemical analysis of Caspase 6 p18 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP6 / Caspase 6 Antibody - Anti-Caspase 6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa130-179) Antibody
Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CASP6 / Caspase 6 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Caspase 6 (Phospho-Ser257) antibody.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP6 / Caspase 6 Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Caspase 6 (Ab-257) antibody.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (p257) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
CASP6 / Caspase 6 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using Caspase 6 (Phospho-Ser257) Antibody. The picture on the right is blocked with the phospho peptide.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (pSer257) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Caspase 6 Antibody. The picture on the right is blocked with the synthesized peptide.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa223-272) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Antibody - 1:100 staining rat heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (Cleaved Asp179) Antibody
Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP6 / Caspase 6 Antibody - Western blot of Caspase-6 antibody
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (200-280 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Antibody - Western blot of Phospho-Caspase-6 (S257) antibody
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (200-280 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP6 / Caspase 6 Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using antibody at 1:100 dilution.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa24-293) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CASP6 / Caspase 6 Antibody - Immunohistochemistry of paraffin-embedded human small intestine tissue using antibody at 1:100 dilution.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal (aa24-293) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
CASP6 / Caspase 6 Antibody - Caspase-6(P18) antibody IHC-paraffin: Rat Spleen Tissue.
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CASP6 / Caspase 6 Rabbit anti-Rat Polyclonal (aa7-27) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP6 / Caspase 6 Antibody - IHC of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide.
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CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (aa144-193) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP6 / Caspase 6 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer at dilution of 1:100
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$546
CASP6 / Caspase 6 Antibody - Formalin-fixed paraffin-embedded tissue section of dog cerebellum stained for Active/Cleaved Caspase-6 expression using Caspase-6 antibody at 1:2000. Hematoxylin-Eosin counterstain.
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CASP6 / Caspase 6 Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP6 / Caspase 6 Antibody - Cl-peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 6 (cleaved-Asp162) antibody.
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CASP6 / Caspase 6 Rabbit anti-Mouse Polyclonal (Cleaved-Asp162) Antibody
Mouse, Rat
ELISA, IHC, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 134 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).