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CASP8 / Caspase 8
caspase 8, apoptosis-related cysteine peptidase
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
| Gene Name: | caspase 8, apoptosis-related cysteine peptidase |
| Family/Subfamily: | Protease , Cysteine C14 |
| Synonyms: | CASP8, ALPS2B, Apoptotic protease Mch-5, Apoptotic cysteine protease, Casp-8, Caspase-8, CAP4, Caspase 8, MACH, MCH5, MORT1-associated ced-3 homolog, ICE-like apoptotic protease 5, Pro Caspase 8, FADD-like ICE, FLICE, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein |
| Target Sequences: | nm_001228 AAC50645.1 Q14790 |
Publications (2)
1
ARHGEF4 predicts poor prognosis and promotes cell invasion by influencing ERK1/2 and GSK-3a/ß signaling in pancreatic cancer. Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Toshiji Saibara. International journal of oncology. 2018 Nov;53:2224-2240. [Full Text Article]
[PubMed:30226582]
Related Antibodies: LS-C344789.
2
BaxDelta2 promotes apoptosis through caspase-8 activation in microsatellite-unstable colon cancer. Zhang H, Lin Y, Ma[Character f1]as A, Zhao Y, Denning MF, Ma L, Xiang J. Molecular cancer research : MCR. 2014 Sep;12:1225-32. [Full Text Article]
[PubMed:24842234]
Related Antibodies: LS-C99287.
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Antibodies
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CASP8 / Caspase 8
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(160)
Yes
(2)
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa432-461) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
CASP8 / Caspase 8 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
CASP8 / Caspase 8 Mouse anti-Human Monoclonal (5F7) Antibody
Human
WB
Unconjugated
100 µg/$425
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pTyr380) Antibody
Rat, Human, Monkey
WB
Unconjugated
100 µl/$315
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (Internal) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
CASP8 / Caspase 8 Mouse anti-Human Monoclonal (aa181-478) (C15) Antibody
Human
ICC, IP, WB
Unconjugated
50 µg/$358; 100 µg/$449
CASP8 / Caspase 8 Mouse anti-Human Monoclonal (FLICE 4-1-20) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa7-216) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$289; 200 µl/$323; 500 µl/$435; 1 ml/$491; 2 ml/$605; 5 ml/$1,045
CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
CASP8 / Caspase 8 Rat anti-Mouse Monoclonal (3B10) Antibody
Mouse
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$414
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pTyr380) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CASP8 / Caspase 8 Rat anti-Mouse Monoclonal (1G12) Antibody
Mouse
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$414
CASP8 / Caspase 8 Mouse anti-Human Monoclonal (1H11) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (aa313-362) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Bovine, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$442
CASP8 / Caspase 8 Mouse anti-Cow Monoclonal (aa25-175) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,393
CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$351
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASP8 / Caspase 8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
CASP8 / Caspase 8 Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
25 µg/$288; 100 µg/$414
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