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EGFR
epidermal growth factor receptor
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.
| Gene Name: | epidermal growth factor receptor |
| Family/Subfamily: | Protein Kinase , EGF Receptor |
| Synonyms: | EGFR, EGF Receptor, ERBB, ERBB1, MENA, PIG61, Proto-oncogene c-ErbB-1, V-erb-b homolog, EGF-R, HER1 |
| Target Sequences: | NM_005228 NP_005219.2 P00533 |
Publications (11)
1
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L314-27. (WB)
[PubMed:17468132]
2
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells. Kumar N, Afeyan R, Kim HD, Lauffenburger DA. Molecular pharmacology. 2008 73:1668-78. (ICC)
[PubMed:18349105]
3
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU, Bae SS, Kim CD. Toxicology and applied pharmacology. 2010 245:76-82. (WB)
[PubMed:20153347]
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Fast Shipping
EGFR Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
EGFR Sheep anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$595
EGFR Sheep anti-Human Polyclonal (Biotin) Antibody
Chicken, Mouse, Rat, Human
ELISA, ICC, IF, IP, WB
Biotin Conjugated
100 µl/$919
EGFR Sheep anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
EGFR Rabbit anti-Human Polyclonal (pThr693) Antibody
Chicken, Zebrafish, Bovine, Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
EGFR Mouse anti-Human Monoclonal (31G7) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$332; 0.5 ml/$570; 1 ml/$797
EGFR Rabbit anti-Human Polyclonal (aa27-57) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
EGFR Mouse anti-Human Monoclonal (31G7) Antibody
Human
IHC, IHC-P
Unconjugated
0.5 ml/$415; 1 ml/$550
EGFR Rat anti-Human Monoclonal (Extracellular Domain) (FITC) (ICR10) Antibody
Human
Flo
FITC Conjugated
0.1 mg/$444
EGFR Rabbit anti-Human Polyclonal (pTyr1068) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$717
EGFR Mouse anti-Human Monoclonal (aa693-893) (5G9B5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
EGFR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
Sandwich
96-Well Microplate
Human
2.74 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$725
EGFR Rabbit anti-Human Polyclonal (Ser1070) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
CHO Cells
His, C-Terminal
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
95-115 kDa (SDS-PAGE)
50 µg/$402; 10 µg/$296; 1 mg/$1,933
EGFR Rabbit anti-Human Polyclonal (aa986-1035) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
EGFR Rabbit anti-Human Polyclonal (Ser1166) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
EGFR Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
EGFR Mouse anti-Human Monoclonal (pTyr1173) Antibody
Mouse, Dog, Rat, Human
ELISA, IP, WB
Unconjugated
100 µg/$845
EGFR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
100 µl/$702
EGFR Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
EGFR Rat anti-Human Monoclonal (Extracellular Domain) (ICR10) Antibody
Human
Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.2 mg/$486
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
EGFR Rabbit anti-Human Polyclonal (aa1004-1033) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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