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HMG1 / HMGB1
high mobility group box 1
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
| Gene Name: | high mobility group box 1 |
| Synonyms: | HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1 |
| Target Sequences: | NM_002128 NP_002119.1 P09429 |
Publications (23)
1
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Journal of virology. 2011 85:146-55. (WB; Human)
[PubMed:20980503]
[PMC:PMC3014182]
2
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. BMC cell biology. 2011 12:17. (ICC, IHC; Mouse)
[PubMed:21545732]
[PMC:PMC3224136]
3
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse)
[PubMed:21641551]
[PMC:PMC3293110]
☰ Filters
Products
Proteins
(33)
Type
Over-Expression Lysate
(2)
Recombinant
(31)
Target
HMG1 / HMGB1
(33)
Application
Bind
(4)
ELISA
(3)
Func
(3)
SDS-PAGE
(4)
Publications
No
(33)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
Fc
(3)
GST
(2)
GST, N-terminus
(1)
His
(5)
His, N-Terminal
(3)
His,C-terminus
(2)
His,N-terminus
(1)
His-T7
(1)
Human IgG1 Fc
(1)
Human IgG1 Fc, N-terminus
(2)
MARI, N-terminus
(2)
Myc-DDK (Flag)
(3)
Species
Human
(26)
Mouse
(3)
Rat
(3)
Source
293T Cells
(1)
CHO Cells
(1)
E. coli
(15)
HEK 293 Cells
(8)
High Five Cells
(1)
Human Cells
(3)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(11)
Low Endotoxin Level
Low endotoxin level
(19)
Biologically Active
Biologically active
(4)
E. coli
His, N-Terminal
26.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
6His, C-terminus
Less than 1 EU/µg (determined by LAL method).
26.0 kDa
1 mg/$2,500; 50 µg/$355
E. coli
His, N-Terminal
26.4 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
His-T7
21.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human HMGB1 consists of 226 amino acids and has a predicted molecular mass of 26.3 kDa. As a result of glycosylation, the apparent molecular mass of rhHMGB1 is approximately 30-34 kDa in SDS-PAGE under reducing conditions.
100 µg/$480; 500 µg/$1,285
HEK 293 Cells
Human IgG1 Fc, N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse HMGB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 475 amino acids and has a calculated molecular mass of 53.3 kDa. The apparent molecular mass of the monomer is approximately 57 kDa in SDS-PAGE under reducing conditions.
50 µg/$410; 500 µg/$1,428
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$512
HEK 293 Cells
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 215 amino acid recombinant protein has a predicted molecular mass of approximately 24.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 38 and 40 kD respectively by SDS-PAGE. The predicted N-terminal amino acid is Met
25 µg/$344
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
24.7 kDa
20 µg/$1,107
E. coli
His
26.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
GST
47.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
Fc
51.3 kDa
10 µg/$372; 50 µg/$742; 100 µg/$1,088
Wheat Germ Extract
GST
49.39 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Human IgG1 Fc, N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human HMGB1/Fc is a disulfide-linked homodimeric protein.The reduced monomer consists of 452 amino acids and has a predictedmolecular mass of 51.5 kDa. As a result of glycosylation, the apparent molecular mass of rhHMGB1/Fc monomer is approximately 55-60 kDa inSDS-PAGE under reducing conditions.
50 µg/$410; 500 µg/$1,428
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
53.3 kDa
50 µg/$854; 500 µg/$2,999
293T Cells
Myc-DDK (Flag)
24.7 kDa
20 µg/$150
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
51.5 kDa
50 µg/$843
E. coli
His, N-Terminal
22kDa
10 µg/$362; 50 µg/$902; 200 µg/$1,553; 100 µg/$1,325; 1 mg/$2,881; 500 µg/$2,369; 5 mg/$6,301; 2 mg/$3,361
HEK 293 Cells
Myc-DDK (Flag)
24.7 kDa
100 µg/$494
E. coli
His,N-terminus
Bind SDS-PAGE
The recombinant human HMGB1 consists of 117 amino acids and predicts a molecular mass of 13.6 kDa. It migrates as an approximately 15 kDa band in SDS-PAGE under reducing conditions.
50 µg/$364
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.3 kDa
100 µg/$926; 500 µg/$2,935
Yeast
6His, N-terminus
100 µg/$446; 50 µg/$347; 20 µg/$336; 1 mg/$1,460
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
25 µg/$400
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
25 µg/$414
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