HNE / Neutrophil Elastase

elastase, neutrophil expressed

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

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Proteins (9)

Type

Native (1)

Over-Expression Lysate (2)

Recombinant (6)

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HNE / Neutrophil Elastase (9)

Publications

No (9)

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6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His-GST (1)

Myc-DDK (Flag) (2)

Species

Human (8)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Yeast (1)

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Human HNE / Neutrophil Elastase Protein (Recombinant 6His, N-terminus) (aa30-267) - LS-G22905

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

27.5 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human HNE / Neutrophil Elastase Protein (Recombinant 6His, N-terminus) (Ile30-His267) - LS-G26599

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

25.6 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949

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Human HNE / Neutrophil Elastase Protein (Recombinant His-GST) (aa30-247) - LS-G11750

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.7 kDa

Price:

10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human HNE / Neutrophil Elastase Protein (Native) - LS-G37572

Tag:

None

Molecular Weight:

28.5 kDa

Price:

0.1 mg/$505

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Human HNE / Neutrophil Elastase Protein (Recombinant GST, N-terminus) (aa168-267) - LS-G64638

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

25 µg/$670; 10 µg/$479

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Human HNE / Neutrophil Elastase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77096

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.52 kDa

Price:

20 µg/$150

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HNE / Neutrophil Elastase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118272

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.52 kDa

Price:

100 µg/$494

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Human HNE / Neutrophil Elastase Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145034

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

53.5 kDa

Price:

50 µg/$419

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Human HNE / Neutrophil Elastase Protein (Recombinant GST) (aa30-267) - LS-G20700

Source:

E. coli

Tag:

GST

Molecular Weight:

52.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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