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NES / Nestin

nestin

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.

Gene Name:	nestin
Synonyms:	NES, Nestin, Nbla00170
Target Sequences:	X65964 CAA46780.1 P48681

Publications (14)

Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody. Messam CA, Hou J, Major EO. Experimental neurology. 2000 161:585-96. [PubMed:10686078]

Analysis of the temporal expression of nestin in human fetal brain derived neuronal and glial progenitor cells. Messam CA, Hou J, Berman JW, Major EO. Brain research. Developmental brain research. 2002 134:87-92. (ICC; Human) [PubMed:11947939]

Gene expression in human neural stem cells: effects of leukemia inhibitory factor. Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN. Journal of neurochemistry. 2003 86:179-95. (ICC; Human) [PubMed:12807438]

SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Gangemi RM, Griffero F, Marubbi D, Perera M, Capra MC, Malatesta P, Ravetti GL, Zona GL, Daga A, Corte G. Stem cells (Dayton, Ohio). 2009 27:40-8. (ICC; Human) [PubMed:18948646]

NK cells recognize and kill human glioblastoma cells with stem cell-like properties. Castriconi R, Daga A, Dondero A, Zona G, Poliani PL, Melotti A, Griffero F, Marubbi D, Spaziante R, Bellora F, Moretta L, Moretta A, Corte G, Bottino C. Journal of immunology (Baltimore, Md. : 1950). 2009 182:3530-9. (ICC; Human) [PubMed:19265131]

Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Ropolo M, Daga A, Griffero F, Foresta M, Casartelli G, Zunino A, Poggi A, Cappelli E, Zona G, Spaziante R, Corte G, Frosina G. Molecular cancer research : MCR. 2009 7:383-92. (ICC; Human) [PubMed:19276180]

Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells. Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS. The Journal of biological chemistry. 2009 284:23806-17. (WB; Human) [PubMed:19542221] [PMC:PMC2749153]

Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas. May R, Sureban SM, Lightfoot SA, Hoskins AB, Brackett DJ, Postier RG, Ramanujam R, Rao CV, Wyche JH, Anant S, Houchen CW. American journal of physiology. Gastrointestinal and liver physiology. 2010 299:G303-10. [PubMed:20522640] [PMC:PMC2928534] Related Antibodies: LS-C97685.

Illumina whole-genome complementary DNA-mediated annealing, selection, extension and ligation platform: assessing its performance in formalin-fixed, paraffin-embedded samples and identifying invasion pattern-related genes in oral squamous cell carcinoma. Loudig O, Brandwein-Gensler M, Kim RS, Lin J, Isayeva T, Liu C, Segall JE, Kenny PA, Prystowsky MB. Human pathology. 2011 42:1911-22. (IHC; Human) [PubMed:21683979]

Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. Kondo S, Wakisaka N, Muramatsu M, Zen Y, Endo K, Murono S, Sugimoto H, Yamaoka S, Pagano JS, Yoshizaki T. Journal of virology. 2011 85:11255-64. (WB; Human) [PubMed:21849440] [PMC:PMC3194961]

Nestin and vimentin colocalization affects the subcellular location of glucocorticoid receptor in cutaneous melanoma. Lai S, Piras F, Spiga S, Perra MT, Minerba L, Piga M, Mura E, Murtas D, Demurtas P, Corrias M, Maxia C, Ferreli C, Sirigu P. Histopathology. 2013 62:487-98. (ICC, IHC; Human) [PubMed:23072594]

T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Gate D, Danielpour M, Rodriguez J Jr, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. Proceedings of the National Academy of Sciences of the United States of America. 2014 111:E3458-66. (IHC; Mouse) [Full Text Article] [PubMed:25082897] [PMC:PMC4143044]

Primary cilia are required in a unique subpopulation of neural progenitors. Tong CK, Han YG, Shah JK, Obernier K, Guinto CD, Alvarez-Buylla A. Proceedings of the National Academy of Sciences of the United States of America. 2014 111:12438-43. (IHC; Mouse) [Full Text Article] [PubMed:25114218] [PMC:PMC4151724]

Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories. Mirzadeh Z, Kusne Y, Duran-Moreno M, Cabrales E, Gil-Perotin S, Ortiz C, Chen B, Garcia-Verdugo JM, Sanai N, Alvarez-Buylla A. Nature communications. 2017 January;8:13759. (Human) [Full Text Article] [PubMed:28067220] [PMC:PMC5477523]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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