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6737 Mowry Ave
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NF-L / NEFL

neurofilament, light polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Gene Name: neurofilament, light polypeptide
Synonyms: NEFL, 68 kDa neurofilament protein, CMT1F, CMT2E, NF68, NF-L, NFL, Neurofilament subunit NF-L, PPP1R110, Neurofilament light polypeptide, CMTDIG
Target Sequences: NM_006158 NP_006149.2 P07196

Publications (5)

1
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse) [PubMed:19427060]
2
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. The EMBO journal. 2011 30:4739-54. [PubMed:21946561] [PMC:PMC3243607]
3
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture. Lukiw WJ, Cong L, Jaber V, Zhao Y. Frontiers in neuroscience. 2018 December;12:896. [Full Text Article] [PubMed:30568571] [PMC:PMC6289986]
4
Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial10<sup> Department of Neurology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea12<sup> Lab for Neurodegenerative Dementia, Department of Anatomy, Ajou University School of Medicine, Suwon 16499, Republic of Korea14<sup> Department of Biomedical Systems Engineering, Korea Po. So Young Moon, Chang Hyung Hong, Jee Hyang Jeong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Byeong C Kim, Kyung Won Park, Hee Kyung Park, Muncheong Choi, Sun Min Lee, Buong-O Chun, Seong-Ho Koh , Sun Ah Park , Hyun-Hee Park, Jeong-Hwa Jin, Eun-Hye Lee, Sue Min Kim , Song Mi Han , Jun Seok Kim, Jungsoon Ha, Seong Hye Choi. Aging. 2021 Jun;13:15898-15916. [Full Text Article] [PubMed:34148030] [PMC:PMC8266338]
5
Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy. Seok Jong Chung , Tae Yong Lee, Yang Hyun Lee, KyoungWon Baik, Jin Ho Jung , Han Soo Yoo, Chang Jae Shim, Hyojin Eom, Ji-Yeon Hong, Dong Joon Kim, Young H Sohn, Phil Hyu Lee. Stem cells international. 2021 Oct;2021:9886877. [Full Text Article] [PubMed:34712335] [PMC:PMC8548132]
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Antibodies (64)
Primary (64)
NF-L / NEFL (64)
Human (55)
Mouse (31)
Rat (26)
Avian (2)
Bovine (7)
Chicken (2)
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Monkey (2)
Opossum (1)
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IHC-P (17)
WB (54)
Flo (3)
ELISA (15)
ICC (8)
IF (13)
IHC-Fx (1)
IP (8)
Peptide-ELISA (2)
rabbit (32)
mouse (27)
goat (1)
chicken (4)
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IgG (13)
IgG1 (13)
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monoclonal mc (27)
polyclonal pc (35)
recombinant monoclonal rmc (2)
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Unconjugated (40)
aa139-234 (8)
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aa295-344 (1)
aa330-343 (1)
aa485-530 (1)
No (64)
NF-L / NEFL Antibody - .
Select
NF-L / NEFL Antibody (clone OTI3G2) LS-C175341
NF-L / NEFL Mouse anti-Human Monoclonal (OTI3G2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NF-L / NEFL Antibody - .
Select
NF-L / NEFL Antibody (aa1-360, clone OTI3G2, Carrier-free) LS-C789098
NF-L / NEFL Mouse anti-Human Monoclonal (aa1-360) (Carrier-free) (OTI3G2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
Select
NF-L / NEFL Antibody (clone DA2) LS-C16795
NF-L / NEFL Mouse anti-Human Monoclonal (DA2) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
200 µg/$890
Select
NF-L / NEFL Antibody (HRP) LS-C548312
NF-L / NEFL Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,129
Select
NF-L / NEFL Antibody (Biotin) LS-C528209
NF-L / NEFL Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,129
Select
NF-L / NEFL Antibody (FITC) LS-C538167
NF-L / NEFL Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,129
Select
NF-L / NEFL Antibody (APC) LS-C518348
NF-L / NEFL Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,129
Select
NF-L / NEFL Antibody (PE) LS-C656333
NF-L / NEFL Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,129
NF-L / NEFL Antibody - Anti-NF-L / NEFL antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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IHC-plus™ NF-L / NEFL Antibody LS-B10376
(4.0) Rating
NF-L / NEFL Chicken anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
NF-L / NEFL Antibody - Cells grown from adult rat brain using method described by Evans et al. (2). Large cell in middle is stained with mouse monoclonal to NF-L clone DA2 (green). Another type of neuronal lineage cell was stained with rabbit polyclonal to alpha-internexin RPCA-a-Int (red). These cells were mitotic but had several characteristics of neurons.
Select
NF-L / NEFL Antibody (clone DA2) LS-C204554
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
NF-L / NEFL Antibody - Anti-NEFL / NF-L antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
PathPlus™ NF-L / NEFL Antibody (clone 2F11) LS-B7182
Cancer
(5.0) Rating
NF-L / NEFL Mouse anti-Human Monoclonal (2F11) Antibody
Opossum, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
NF-L / NEFL Antibody - IHC of paraffin-embedded lung cancer tissues using NEFL mouse monoclonal antibody with DAB staining.
Select
NF-L / NEFL Antibody (clone 2G10) LS-C169461
NF-L / NEFL Mouse anti-Human Monoclonal (2G10) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NF-L / NEFL Antibody - Neurofilament staining of cultured neurons (green) with the Neurofilament light chain antibody. Nuclei are stained blue.
Select
NF-L / NEFL Antibody (clone DA2) LS-C2725
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Avian, Pig, Mammal, Mouse, Rat, Human
IF, IHC, IHC-Fx, IHC-P, WB
Unconjugated
0.05 ml/$386
NF-L / NEFL Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
IHC-plus™ NF-L / NEFL Antibody (aa295-344) LS-B12562
(4.0) Rating
NF-L / NEFL Rabbit anti-Human Polyclonal (aa295-344) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100 µl/$515
NF-L / NEFL Antibody - Embryonic rat cortical cells grown in tissue culture and stained with NF-L / NEFL antibody (green) and the phosphorylated axonal form of neurofilament NF-H, using NF-H antibody (red). The perikaryal and dendritic neurofilaments in the Large cell in middle are stained with NF-L / NEFL antibody but not with the phosphorylated NF-H antibody. In contrast both antibodies stain axonal neurofilaments which therefore appear orange.
Select
NF-L / NEFL Antibody (clone 7D1) LS-C204557
NF-L / NEFL Mouse anti-Human Monoclonal (7D1) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
NF-L / NEFL Antibody - NEFL Antibody in Immunohistochemistry (IHC)
Select
NF-L / NEFL Antibody (clone 1H3) LS-C759677
NF-L / NEFL Mouse anti-Human Monoclonal (1H3) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
NF-L / NEFL Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PathPlus™ NF-L / NEFL Antibody LS-B16940
Cancer
(5.0) Rating
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
NF-L / NEFL Antibody - IHC of paraffin-embedded lung cancer tissues using NEFL mouse monoclonal antibody with DAB staining.
Select
NF-L / NEFL Antibody (clone 1H3) LS-C169458
NF-L / NEFL Mouse anti-Human Monoclonal (1H3) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NF-L / NEFL Antibody - Mixed neuron/glia cultures from newborn rat brain stained with antibody to peripherin (green) and rabbit polyclonal antibody to NF-L NF-L / NEFL antibody (red channel). A class of large neurons, like the one in the middle of this image, contain peripherin, while the majority of neurons and their processes contain NF-L and not peripherin. Interestingly, the peripherin positive cells often contain a cytoplasmic inclusion next to the nucleus which stains for both peripherin and NF-L, and so appears golden in this kind of image. The blue channel reveals the localization of DNA.
Select
NF-L / NEFL Antibody LS-C204558
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$376
NF-L / NEFL Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
Select
NF-L / NEFL Antibody (aa128-271) LS-C682222
NF-L / NEFL Rabbit anti-Human Polyclonal (aa128-271) Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
NF-L / NEFL Antibody (aa128-271, Biotin) LS-C678794
NF-L / NEFL Rabbit anti-Human Polyclonal (aa128-271) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
NF-L / NEFL Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using NEFL antibodyat dilution of 1:200 (40x lens).
Select
NF-L / NEFL Antibody LS-C330877
NF-L / NEFL Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NF-L / NEFL Antibody - Western blot of recombinant NF-L / NEFL. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NF-L / NEFL Antibody (aa281-396, Biotin) LS-C300203
NF-L / NEFL Rabbit anti-Human Polyclonal (aa281-396) (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596
NF-L / NEFL Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
IHC-plus™ NF-L / NEFL Antibody (C-Terminus) LS-B16081
(4.0) Rating
NF-L / NEFL Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
IHC-P, WB
Unconjugated
50 µl/$460
NF-L / NEFL Antibody - Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PathPlus™ NF-L / NEFL Antibody (clone NEFL/2983R) LS-B16308
Cancer
(5.0) Rating
NF-L / NEFL Rabbit anti-Human Recombinant Monoclonal (NEFL/2983R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
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