NFKB1 / NF-Kappa-B

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

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IHC-plus™ NFKB1 / NF-Kappa-B Antibody (clone 4D1) LS-B1668

(5.0) Rating

(4) Publication(s)

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (4D1) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ NFKB1 / NF-Kappa-B Antibody (aa1-15, clone NF5E6) LS-B2582

(4.0) Rating

Antibody:

NFKB1 / NF-Kappa-B Rat anti-Human Monoclonal (aa1-15) (NF5E6) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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NFKB1 / NF-Kappa-B Antibody (N-Terminus) LS-B8072

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Chicken, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ NFKB1 / NF-Kappa-B Antibody (N-Terminus) LS-B716

(5.0) Rating

(1) Publication(s)

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, GS, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

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NFKB1 / NF-Kappa-B Antibody (C-Terminus) LS-C112312

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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Dog NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F18607

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Dog

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F21577

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human Phospho-NFKB1 / NF-Kappa-B (Ser337) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F891

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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NFKB1 / NF-Kappa-B Antibody (clone 5D10D11) LS-C169384

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (5D10D11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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NFKB1 / NF-Kappa-B Antibody (clone 3F6) LS-C133346

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (3F6) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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NFKB1 / NF-Kappa-B Antibody (phospho-Ser337) LS-C356228

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (pSer337) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$315

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NFKB1 / NF-Kappa-B Antibody (Internal) LS-C352581

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Chicken, Mouse, Dog, Rat, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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NFKB1 / NF-Kappa-B Antibody (clone 5D10) LS-C169374

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (5D10) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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Mouse NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F12149

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F21089

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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IHC-plus™ NFKB1 / NF-Kappa-B Antibody (N-Terminus) LS-B395

(4.0) Rating

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

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NFKB1 / NF-Kappa-B Antibody LS-C814033

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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NFKB1 / NF-Kappa-B Antibody (clone 5D10D11) LS-C759228

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (5D10D11) Antibody

Reactivity:

Human

Applications:

ChIP-Seq, Flo, ICC, IF, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$541

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NFKB1 / NF-Kappa-B Antibody (clone 4A11) LS-C133345

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal (4A11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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NFKB1 / NF-Kappa-B Antibody (Biotin) LS-C528248

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,177

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NFKB1 / NF-Kappa-B Antibody LS-C812720

Antibody:

NFKB1 / NF-Kappa-B Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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NFKB1 / NF-Kappa-B Antibody (phospho-Ser927) LS-C352572

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (pSer927) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

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NFKB1 / NF-Kappa-B Antibody (C-Terminus) LS-C358828

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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NFKB1 / NF-Kappa-B Antibody LS-C746899

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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NFKB1 / NF-Kappa-B Antibody LS-C801574

Antibody:

NFKB1 / NF-Kappa-B Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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