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TPSAB1 / Mast Cell Tryptase

Tryptase alpha/beta 1

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Gene Name: Tryptase alpha/beta 1
Family/Subfamily: Protease , Serine S1
Synonyms: TPSAB1, Alpha tryptase, Mast cell alpha II tryptase, Tryptase alpha-1, Tryptase beta I, Tryptase-III, TPSB1, Tryptase alpha II, TPS1, TPS2, Tryptase beta-1, Tryptase-1, Tryptase-I, Mast cell beta I tryptase, Tryptase alpha/beta 1, Tryptase alpha/beta-1, Tryptase beta 1, Tryptase I
Target Sequences: NM_003294 NP_003285.2 Q15661

Publications (2)

1
PTH promotes allograft integration in a calvarial bone defect. Sheyn D, Cohn Yakubovich D, Kallai I, Su S, Da X, Pelled G, Tawackoli W, Cook-Weins G, Schwarz EM, Gazit D, Gazit Z. Molecular pharmaceutics. 2013 10:4462-71. (WB; Mouse) [Full Text Article] [PubMed:24131143] [PMC:PMC3902084] Related Antibodies: LS-C18207.
2
Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma. Sehmi R, Lim HF, Mukherjee M, Huang C, Radford K, Newbold P, Boulet LP, Dorscheid D, Martin JG, Nair P. The Journal of allergy and clinical immunology. 2018 April;141:1529-1532 e8. [Full Text Article] [PubMed:29382593]

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Antibodies (89)
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TPSAB1 / Mast Cell Tryptase (112)
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TPSAB1 / Mast Cell Tryptase Antibody - Anti-TPSAB1 / Mast Cell Tryptase antibody IHC of human breast, mast cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (AA1) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P
Unconjugated
0.05 mg/$460
TPSAB1 / Mast Cell Tryptase Antibody - Human Colon, mast cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TPSAB1 / Mast Cell Tryptase Antibody - Anti-TPSAB1 / Mast Cell Tryptase antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (AA1) Antibody
Dog, Cat, Human, Monkey
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$585
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (HRP) (AA1) Antibody
Dog, Rat, Cat, Human, Monkey
ELISA, IF, IHC, WB
HRP Conjugated
100 µl/$951
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (Biotin) Antibody
Dog, Rat, Cat, Human, Monkey
ELISA, IF, IHC, WB
Biotin Conjugated
100 µl/$951
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (PE) Antibody
Dog, Rat, Cat, Human, Monkey
ELISA, IF, IHC, WB
PE Conjugated
100 µl/$951
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TPSAB1 / Mast Cell Tryptase Goat anti-Mouse Polyclonal (aa29-273) Antibody
Mouse
IP, WB
Unconjugated
50 µg/$538; 100 µg/$887
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TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal (aa61-87) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal (aa61-87) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal (aa61-87) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
TPSAB1 / Mast Cell Tryptase Antibody - Western blot analysis of extracts of various cell lines.
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TPSAB1 / Mast Cell Tryptase Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
TPSAB1 / Mast Cell Tryptase Antibody - Immunoperoxidase of monoclonal antibody to TPSAB1 on formalin-fixed paraffin-embedded human lymph node (antibody concentration 1 ug/ml).
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (2A10-B5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
TPSAB1 / Mast Cell Tryptase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
TPSAB1 / Mast Cell Tryptase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
TPSAB1 / Mast Cell Tryptase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
TPSAB1 / Mast Cell Tryptase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$632
TPSAB1 / Mast Cell Tryptase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
TPSAB1 / Mast Cell Tryptase ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
TPSAB1 / Mast Cell Tryptase Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (C10) Antibody
Human
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
TPSAB1 / Mast Cell Tryptase Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (C16) Antibody
Human
ICC, IHC-P, WB
Unconjugated
50 µl/$460
TPSAB1 / Mast Cell Tryptase Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (ABT-MCT) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$460
TPSAB1 / Mast Cell Tryptase Antibody - Human Breast, Mast Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPSAB1 / Mast Cell Tryptase Mouse anti-Human Monoclonal (G3) Antibody
Human
IHC-P
Unconjugated
0.1 ml/$320
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TPSAB1 / Mast Cell Tryptase Goat anti-Mouse Polyclonal (aa22-276) Antibody
Mouse
ELISA, IP, Neut, WB
Unconjugated
100 µg/$929
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TPSAB1 / Mast Cell Tryptase Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
TPSAB1 / Mast Cell Tryptase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Viewing 1-25 of 112 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).