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TJP1 / ZO-1

tight junction protein 1

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

Gene Name:	tight junction protein 1
Family/Subfamily:	Occludin , Not assigned-Occludin
Synonyms:	TJP1, ZO-1, Zona occludens protein 1, Zona occludens 1, Zonula occludens protein 1, Tight junction protein 1, ZO1, Tight junction protein ZO-1, Zonula occludens 1 protein
Target Sequences:	NM_003257 NP_003248.3 Q07157

Publications (11)

A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB. PloS one. 2015 10:e0121707. (ICC, IHC-P; Human) [Full Text Article] [PubMed:25826270] [PMC:PMC4380339]

Tricellulin Expression and its Deletion Effects in the Endolymphatic Sac. Ai Matsubara, Takenori Miyashita, Ryuhei Inamoto, Hirofumi Sakaguchi, Toru Kamitani, Nozomu Mori, Hiroshi Hoshikawa. The journal of international advanced otology. 2018 August;14:312-316. [Full Text Article] [PubMed:30100545] [PMC:PMC6354451] Related Antibodies: LS-C124822.

Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation. Anuj Tharakan, Ashleigh A Halderman, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan Jr. International forum of allergy & rhinology. 2016 November;6:1145-1150. [Full Text Article] [PubMed:27580429] [PMC:PMC5097009] Related Antibodies: LS-C354905.

Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. Nora Freyer, Fanny Knöspel, Nadja Strahl, Leila Amini, Petra Schrade, Sebastian Bachmann, Georg Damm, Daniel Seehofer, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger. BioResearch Open Access. 2016 Aug;5:235-48. [Full Text Article] [PubMed:27610270] [PMC:PMC5003005]

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions. Yao-Tseng Wen, Ching-Wen Huang, Chih-Peng Liu, Chih-Hung Chen, Chia-Mu Tu, Chrong-Shiong Hwang, Yi-Hsun Chen, Wan-Ru Chen, Keh-Liang Lin, Yu-Chieh Ho, Ta-Ching Chen , Rong-Kung Tsai. The Breast : official journal of the European Society of Mastology. 2021 May;62:21. [Full Text Article] [PubMed:34015079] [PMC:PMC8142697] Related Antibodies: LS-B9774.

Dietary 25-Hydroxyvitamin D3 Supplementation Modulates Intestinal Cytokines in Young Broiler Chickens. Gerardo A Abascal-Ponciano, Samuel F Leiva, Joshua J Flees, Luis P Avila, Jessica D Starkey, Charles W Starkey. Frontiers in veterinary science. 2022 July;9:947276. [Full Text Article] [PubMed:35898543] [PMC:PMC9309538] Related Antibodies: LS-C145545.

AMPK modulation ameliorates dominant disease phenotypes of CTRP5 variant in retinal degeneration. Kiyoharu J Miyagishima , Ruchi Sharma , Malika Nimmagadda , Katharina Clore-Gronenborn, Zoya Qureshy, Davide Ortolan, Devika Bose, Mitra Farnoodian, Congxiao Zhang, Andrew Fausey, Yuri V Sergeev, Mones Abu-Asab, Bokkyoo Jun, Khanh V Do, Marie-Audrey Kautzman Guerin, Jorgelina Calandria, Aman George, Bin Guan, Qin Wan, Rachel C Sharp, Catherine Cukras, Paul A Sieving, Robert B Hufnagel, Nicolas G Bazan, Kathleen Boesze-Battaglia, Sheldon Miller, Kapil Bharti. Communications biology. 2021 December;4:1360. [Full Text Article] [PubMed:34887495] [PMC:PMC8660775] Related Antibodies: LS-B9774.

Urothelial cell expansion and differentiation are improved by exposure to hypoxia. Stéphane Chabaud, Ingrid Saba, Clément Baratange, Brice Boiroux, Maude Leclerc, Alexandre Rousseau, Sara Bouhout, Stéphane Bolduc. Journal of tissue engineering and regenerative medicine. 2017 November;11:3090-3099. [Full Text Article] [PubMed:28156053] Related Antibodies: LS-B5625.

Induction of Human Umbilical Mesenchymal Stem Cell Differentiation Into Retinal Pigment Epithelial Cells Using a Transwell-Based Co-culture System. Yu-Hsun Chang, V Bharath Kumar, Yao-Tseng Wen, Chih-Yang Huang, Rong-Kung Tsai, Dah-Ching Ding. Cell transplantation. 2022 March;31:9636897221085901. [Full Text Article] [PubMed:35321565] [PMC:PMC8961389] Related Antibodies: LS-B9774.

Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery. Sophie Dithmer, Christian Staat, Carolin Müller, Min-Chi Ku, Andreas Pohlmann, Thoralf Niendorf, Nora Gehne, Petra Fallier-Becker, Ágnes Kittel, Fruzsina R Walter, Szilvia Veszelka, Maria A Deli, Rosel Blasig, Reiner F Haseloff, Ingolf E Blasig, Lars Winkler. Annals of the New York Academy of Sciences. 2017 June;1397:169-184. [Full Text Article] [PubMed:28505395] Related Antibodies: LS-C124822.

Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. Short SS, Wang J, Castle SL, Fernandez GE, Smiley N, Zobel M, Pontarelli EM, Papillon SC, Grishin AV, Ford HR. Laboratory investigation; a journal of technical methods and pathology. 2013 93:1265-75. (WB; Human) [Full Text Article] [PubMed:24126890] Related Antibodies: LS-B2129.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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