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CASP3 / Caspase 3

caspase 3, apoptosis-related cysteine peptidase

CASP3 / Caspase 3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Gene Name:	caspase 3, apoptosis-related cysteine peptidase
Family/Subfamily:	Protease , Cysteine C14
Synonyms:	CASP3, Apopain, CASP-3, Caspase-3, CPP32B, CPP32, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Procaspase3, Caspase 3, CPP-32, PARP cleavage protease, Protein Yama
Target Sequences:	NM_004346 NP_004337.2 P42574

Publications (16)

Caspase-9 and APAF-1 form an active holoenzyme. Rodriguez J, Lazebnik Y. Genes & development. 1999 13:3179-84. [PubMed:10617566] [PMC:PMC317200]

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:19488-93. [PubMed:18042711] [PMC:PMC2148316]

Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy. Tanaka K, Hashimoto H, Tachibana T, Ishikawa H, Ohki T. Pediatric surgery international. 2008 24:837-42. (IHC) [PubMed:18470518]

Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:2417-25. [PubMed:19318489]

Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis. Gould Rothberg BE, Bracken MB, Rimm DL. Journal of the National Cancer Institute. 2009 101:452-74. [PubMed:19318635] [PMC:PMC2720709]

Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568. Hsu LC, Hsu YW, Liang YH, Kuo YH, Pan TM. Journal of agricultural and food chemistry. 2011 59:1124-30. (WB; Mouse) [PubMed:21261255]

Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:8785-90. (WB, IP; Human) [PubMed:21555592] [PMC:PMC3102401]

Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. Hsu LC, Hsu YW, Liang YH, Liaw CC, Kuo YH, Pan TM. Molecules (Basel, Switzerland). 2012 17:664-73. [PubMed:22237681]

Regulation of TGF-1 expression by androgen deprivation therapy of prostate cancer. Fuzio P, Ditonno P, Rutigliano M, Battaglia M, Bettocchi C, Loverre A, Grandaliano G, Perlino E. Cancer letters. 2012 318:135-44. (IHC; Human) [PubMed:22269108]

Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep. Regan JK, Kannan PS, Kemp MW, Kramer BW, Newnham JP, Jobe AH, Kallapur SG. Reproductive sciences (Thousand Oaks, Calif.). 2016 January;23:69-80. (Human) [Full Text Article] [PubMed:26156854] [PMC:PMC5933192]

IL-1ß Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Thiyagarajan D, Pedersen HL, Seredkina N, Horvei KD, Arranz L, Sonneveld R, Nijenhuis T, van der Vlag J, Rekvig OP. Frontiers in cell and developmental biology. 2018 February;6:7. (Human) [Full Text Article] [PubMed:29468159] [PMC:PMC5807897] Related Antibodies: LS-B2125.

Apoptosis induced by boric anhydrite (B2O3) after partial hepatectomy in rat liver. A Ozen, M Canbek. Bratislavske lekarske listy. 2016 April;117:231-4. [Full Text Article] [PubMed:27075388]

In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration10<sup> Research Programs Unit, Stem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland12<sup> Department of Neurology, Neuro-SysMed, Haukeland University Hospital, Bergen, Norway14<sup> Folkhälsan Research Center, Helsinki, Finland. hannes.lohi@helsinki.fi. Marjo K Hytönen , Riika Sarviaho , Christopher B Jackson, Pernilla Syrjä, Tarja Jokinen , Kaspar Matiasek, Marco Rosati, Cristina Dallabona, Enrico Baruffini, Ileana Quintero , Meharji Arumilli , Geoffray Monteuuis, Jonas Donner, Marjukka Anttila, Anu Suomalainen, Laurence A Bindoff , Hannes Lohi. Human genetics. 2021 Nov;;140:1593-1609. [Full Text Article] [PubMed:33835239] [PMC:PMC8519929] Related Antibodies: LS-C148242.

FOXD1-mTOR Signaling Pathway on Oral Squamous Cell Carcinoma and Its Inhibition by Rosemary Extract (Invitro-Study). Yasmine Alaa El-Din, Dina Sabry, Sahar H Ahmed, Abbas Mohamed. Asian Pacific journal of cancer prevention : APJCP. 2022 September;23:3071-3081. [Full Text Article] [PubMed:36172670] [PMC:PMC9810292]

Overexpression of facioscapulohumeral muscular dystrophy region gene 1 causes primary defects in myogenic stem cells. Xynos A, Neguembor MV, Caccia R, Licastro D, Nonis A, Di Serio C, Stupka E, Gabellini D. Journal of cell science. May;126:2236-45. [Full Text Article] [PubMed:23525014] Related Antibodies: LS-C12476.

Prevention of Anti-microbial Peptide LL-37-Induced Apoptosis and ATP Release in the Urinary Bladder by a Modified Glycosaminoglycan. Lee WY, Savage JR, Zhang J, Jia W, Oottamasathien S, Prestwich GD. PloS one. 2013 30-Oct; [Full Text Article] [PubMed:4204996] Related Antibodies: LS-C12499.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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